It is laid out either horizontally or vertically for consistent substances.It does not overlap and is not flipped/mirrored.It does not extend beyond the 0-1 UV space.
The low polymesh has soft normals (single smoothing group) so that all the hard edged information is held inside the normal map.However, consider the following pointsfor the low resolution (or low poly) mesh that you create. So you can create use topology and UV layout for the custom clothing. Unlike the custom body, the custom clothing does not have any specific UV requirements.
